Urolithin A and age-related immune decline (2025)
Human RCT — biomarker endpoint
Record verify: verified against primary source
| Design | Randomized, placebo-controlled trial (biomarker) |
| DOI | 10.1038/s43587-025-00996-x |
| Citation status | doi verified via Crossref 2026-07-12 (Nature Aging 2025;5:2309-2322, 'Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial'). PMID and trial registry ID are not confirmed; see identifier status. |
Identifiers: DOI verified; PMID not reported; trial registry id not reported. Record-level verification and identifier-level status are separate: a record can be verified against its primary publication on one identifier while another is simply not confirmed. No identifier is fabricated, and none is left in a “pending” state.
Five-qualifier claim
| Species / population | Older adults with age-related immune decline (randomized, placebo-controlled trial). |
| Exposure, route, schedule | Oral urolithin A for several months. |
| Comparator / duration | Placebo-controlled, randomized. |
| Endpoint / numeric result | Reported improvements in immune-cell/mitochondrial biomarkers associated with aging immune function. |
| What it did NOT establish | Immune-biomarker endpoints — not a functional disability, disease-outcome, or lifespan endpoint, and not a healthy-aging-longevity result. |
Interventions
What this trial administered
These are the compounds this trial administered, nothing more. MitoiX does not rank products, name a best one, or suggest a dose — read the record above and the primary reference, then talk to a clinician.
- Urolithin A (Mitopure) — Urolithin A (Mitopure)
Studied form: Mitopure, 500-1000 mg/day in the human trials
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Primary reference
https://doi.org/10.1038/s43587-025-00996-x
Exact identifier confirmed against the primary record via Crossref/ClinicalTrials.gov where stated in the citation status names the source and the date. An identifier that is not confirmed is named as such in the identifier row above, never filled in from a secondary source.