Methodology
How evidence tiers and honesty flags are assigned.
Evidence tiers
Evidence is shown on a visible seven-tier scale (1 = healthy-aging human lifespan RCT, down to 7 = in vitro/mechanism) and is never collapsed into a single marketing score. Tier 1 is empty on this site by design: no mitochondrial intervention has a healthy-aging lifespan RCT. Note the deliberate distinction between tier 2 (a human clinical-outcome RCT in a disease population, e.g. CoQ10 mortality in heart failure) and a healthy-aging lifespan result — the former is real and important, but it is disease treatment, not evidence of an anti-aging effect.
Honesty flag
Each intervention carries a flag derived by string classification of its human-evidence field: ● available is reserved for a genuine healthy-aging human lifespan RCT; ▲ qualified marks human data that is functional, biomarker, disease-outcome, failed, ongoing, or rare-disease grade — i.e. not a healthy-aging lifespan RCT; ○ none marks animal/preclinical-only, thin, or mechanism nodes. The classifier generalizes across the longevity cluster with zero data fabrication.
Unverified identifiers
Journal, volume, and DOI were confirmed via Crossref, and trial design/status via the
ClinicalTrials.gov v2 API where an NCT was resolvable. Where an exact NCT/PMID could not be confirmed
against the primary record at build time, the record is tagged needs_primary_fulltext and no
identifier is invented. These are confirmed against the primary record before deployment.