Study record
Urolithin A induces mitophagy and prolongs lifespan in C. elegans and improves rodent muscle (Ryu et al., 2016)
Animal healthspan / lifespan study
○ Evidence tier 6 — Animal healthspan / lifespan study
Record verify: primary source pending
| Design | Preclinical mitophagy + lifespan/function study (C. elegans + rodent) |
| DOI | 10.1038/nm.4132 |
| Citation status | doi verified via Crossref 2026-07-12 (Nat Med 2016;22(8):879-888, Ryu et al., 'Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents'). PMID: needs_primary_fulltext. |
Five-qualifier claim
| Species / population | C. elegans and rodents (mouse/rat). |
| Exposure, route, schedule | Dietary urolithin A. |
| Comparator / duration | Vehicle/untreated controls. |
| Endpoint / numeric result | Induced mitophagy, prolonged lifespan in C. elegans, and improved muscle function in rodents — the preclinical basis for the urolithin A program. |
| What it did NOT establish | Invertebrate lifespan and rodent muscle gains are animal results; they do not establish any human lifespan or healthy-aging effect. |
Interventions
Primary reference
https://doi.org/10.1038/nm.4132
Exact identifier confirmed against the primary record via Crossref/ClinicalTrials.gov where stated in the citation status; anything marked needs_primary_fulltext is not yet confirmed.