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Study record

Q-SYMBIO: CoQ10 reduces mortality in chronic heart failure (Mortensen et al., 2014)

Human clinical-outcome RCT — disease population

Randomized, double-blind, placebo-controlled multicentre trial (mortality outcome)
○ Evidence tier 2 — Human clinical-outcome RCT — disease population

Record verify: verified against primary source

DesignRandomized, double-blind, placebo-controlled multicentre trial (mortality outcome)
N420
DOI10.1016/j.jchf.2014.06.008
Citation statusdoi verified via Crossref 2026-07-12 (JACC Heart Fail 2014;2(6):641-649, Mortensen et al., 'The Effect of Coenzyme Q10 on Morbidity and Mortality in Chronic Heart Failure' — the Q-SYMBIO trial). PMID and trial registry ID are not confirmed; see identifier status.

Identifiers: DOI verified; PMID not reported; trial registry id not reported. Record-level verification and identifier-level status are separate: a record can be verified against its primary publication on one identifier while another is simply not confirmed. No identifier is fabricated, and none is left in a “pending” state.

Five-qualifier claim

Species / populationAdults with chronic (NYHA class III-IV) heart failure (n=420) — a DISEASE population, not healthy aging.
Exposure, route, scheduleOral CoQ10 100 mg three times daily on top of standard heart-failure therapy.
Comparator / durationPlacebo-controlled, randomized, double-blind; ~2-year follow-up.
Endpoint / numeric resultFewer major adverse cardiovascular events and lower all-cause mortality vs placebo in the heart-failure population.
What it did NOT establishThis is heart-failure disease treatment — it is NOT evidence of a healthy-aging, longevity, or lifespan-extension benefit in the general population.

Interventions

Primary reference

https://doi.org/10.1016/j.jchf.2014.06.008

Exact identifier confirmed against the primary record via Crossref/ClinicalTrials.gov where stated in the citation status names the source and the date. An identifier that is not confirmed is named as such in the identifier row above, never filled in from a secondary source.